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Alzheimer's disease - SPECT

Case contributed by: Dr Carlos Eduardo Anselmi

Presentation:

Memory deficit

From the case: Alzheimer's disease - SPECT
Modality: Nuclear medicine

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  • <p>SPECT - 99MTC-ECD</p> Bilateral temporoparietal hypoperfusion

SPECT - 99MTC-ECD

Bilateral temporoparietal hypoperfusion

Case Discussion:

Brain perfusion with 99mTc-ECD shows bilateral temporoparietal hypoperfusion.

Different perfusion patterns have the following probabilities of AD:

  • Normal: 19%
  • Bilateral temporoparietal hypoperfusion: 82%
  • Bilateral temporoparietal hypoperfusion and other defects: 77%
  • Unilateral temporoparietal hypoperfusion: 57%
  • Frontal hypoperfusion: 43%
  • Other large defects: 18%
  • Multiple small defects: 0%

Holman BL, Johnson KA, Gerada B et-al. The scintigraphic appearance of Alzheimer's disease: a prospective study using technetium-99m-HMPAO SPECT. J. Nucl. Med. 1992;33 (2): 181-5. J. Nucl. Med. (link) - Pubmed citation

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