Oligoastrocytoma NOS - anaplastic

Case contributed by Frank Gaillard
Diagnosis almost certain

Presentation

Seizures.

Patient Data

Age: 60 years
Gender: Male

The anterior most part of the left superior frontal gyrus demonstrates cortical increase in T2/FLAIR signal and enhancement. No restricted diffusion or calcification.

Case Discussion

The patient went on to have a biopsy which demonstrates an anaplastic oligoastrocytoma (path proven). 

NOTE: This case predates the 2016 WHO classification of CNS tumor revision. As no 1p19q co-deletion status is available a formal diagnosis cannot be reached and the NOS is therefore used (not otherwise specified) - which is recognized in the current classification for cases where molecular information is unavailable. It should also be noted, that under the new classification both an astrocytic and oligodendroglial component needs to be identified, each with its own molecular markers. True oligoastrocytomas are therefore going to be rare, and this case would most likely be classified as either an astrocytoma or an oligodendroglioma.

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