Glioblastoma NOS

Case contributed by Hani Makky Al Salam
Diagnosis certain

Presentation

Headaches.

Patient Data

Age: 30 years
Gender: Female

Note: This case has been tagged as "legacy" as it no longer meets image preparation and/or other case publication guidelines.

mri

Large heterogeneously enhancing mass with regions of peripheral nodularity. The adjacent cortex is thickened. Marked elevation of choline. 

Case Discussion

The patient went on to have a resection which confirmed the diagnosis of glioblastoma.

Histology

  • Neoplastic cells positive for GFAP (polyclonal)
  • Negative for EMA
  • Strong nuclear staining for P53 (D0-7)
  • Ki-67 positive in 15%

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as a glioblastoma NOS.

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