Glioblastoma multiforme - multifocal
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Multifocal / multicentric GBM
Temporal lobe lesion: Glioblastoma multiforme.
Sections show a densely cellular glial neoplasm. The tumour cells have hyperchromatic, pleomorphic nuclei and abundant eosinophilic cytoplasm with fibrillary processes. There are areas where the tumour cells have scant cytoplasm and round nuclei that could represent focal oligodendroglial differentiation. Mitotic figures are frequent and there is abundant endothelial proliferation and tumour necrosis with pseudopalisading.