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Glioblastoma multiforme - multifocal

Case contributed by: Dr Frank Gaillard

Patient Data:

Age: Adult
Modality: MRI

Case Discussion:

Multifocal / multicentric GBM

Final Diagnosis:

Temporal lobe lesion: Glioblastoma multiforme.

Microscopic Description:

Sections show a densely cellular glial neoplasm. The tumour cells have hyperchromatic, pleomorphic nuclei and abundant eosinophilic cytoplasm with fibrillary processes. There are areas where the tumour cells have scant cytoplasm and round nuclei that could represent focal oligodendroglial differentiation. Mitotic figures are frequent and there is abundant endothelial proliferation and tumour necrosis with pseudopalisading.

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