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Lung metastases from uterine sarcoma

Case contributed by: Dr Bruno Di Muzio

Presentation:

Patient with uterine leiomyosarcoma follow-up.

Patient Data:

Age: 77
Gender: Female
Race: Caucasian
Modality: X-ray

Large pulmonary nodules distributed in the left lung.

Modality: CT

Large pulmonary nodules distributed in the left lung.

Case Discussion:

Study to determine the sites and possible modes of uterine sarcoma metastasis shows the peritoneal cavity and omentum were the most frequently involved sites (59%), followed by the lung (52%), pelvic lymph nodes (41%), paraaortic lymph nodes (38%), and liver parenchyma (34%)1

The presence of lung metastasis was not associated with pelvic or paraaortic node metastasis or intraperitoneal disease. Metastasis to other distant sites including the brain, heart, kidney, and bone were independent of pelvic and paraaortic nodal metastasis or intraperitoneal disease1.

Metastatic sites were not different among various histologic types of uterine sarcoma. Distant metastatic sites were statistically associated with lung metastasis. Hematogenous metastasis best explains this metastatic pattern and adjuvant systemic therapy seems indicated1.

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