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Osteogenesis imperfecta and bisphosphonate lines

Case contributed by Dr Michael Sargent

Patient Data:

Age: 10 months
Gender: Female
Modality: X-ray

Osteopaenic, gracile bones with zebra stripes. Evidence of prior right femoral fracture. 

Case Discussion:

Baby girl with type II osteogenesis imperfecta, treated with cyclical bisphosphonate therapy (pamidronate) resulting in the "zebra stripe sign". Also note the wormian bones on the skull x-ray.

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