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Pan-lobular emphysema due to alpha-1-antitrypsin deficiency

Case contributed by Dr Jeremy Jones


49 year old male with severe breathlessness and recurrent infections

Case Discussion:

Pan-lobular emphysema with characteristic basal predominance. Severe destruction of the basal segments.  Widespread tracheal diverticulae that extend into the lower bronchial tree - associated with severe emphysema.

Subsequent investigation confirmed alpha-1-antitrypsin deficiency.

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