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Particle disease: total hip replacement

Case contributed by Dr Maarten Borg


Pain in right hip and knee 10 years after total hip replacement.

Patient Data:

Age: 76
Gender: Female
Modality: X-ray

To be added

Case Discussion:

Released cement particles trigger the release of inflammatory mediators. Local accumulation of inflammatory mediators produces a local giant cell granulomatous reaction and leads to osteolysis and formation of cystic change in adjacent bone. This process is referred to as particle disease, and is a significant cause of revision surgery. 

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