899 results found
Article

Birbeck granules

Birbeck granules refer to unusual rod-shaped structures specific to Langerhans cells. Their origin and function remain undetermined. Langerin is a crucial component within Birbeck granules. History and etymology Birbeck granules were first described by Michael S Birbeck in 1961 3. Related pat...
Case

Anaplastic large cell lymphoma (ALK positive): encircling right brachial plexus

  Diagnosis almost certain
Domagoj Kretic
Published 15 Jan 2014
78% complete
CT Ultrasound MRI
Case

Thalassemia - spine MRI

  Diagnosis certain
Ian Bickle
Published 12 Aug 2015
95% complete
Annotated image MRI
Article

Infectious mononucleosis

Infectious mononucleosis (also known as glandular fever) is the term for infection with Epstein-Barr virus (EBV). The infection classically occurs in teenagers and young adults, hence its popular name kissing disease. It is usually a clinical diagnosis, with confirmation by serum testing, but ma...
Article

Marginal zone lymphoma

Marginal zone lymphomas are a group of low grade non-Hodgkin lymphoma that arise from the marginal zone of B cell germinal follicles in lymph nodes. There are three types of marginal zone lymphomas depending on the site of origin, namely mucosa-accosiated lymphoid tissue (MALT), splenic and extr...
Case

Mantle B cell lymphoma

  Diagnosis certain
Bruno Di Muzio
Published 05 Jun 2017
89% complete
CT MRI X-ray
Article

Hematopoietic stem cell transplantation (abdominal complications)

Abdominal complications of hematopoietic stem cell transplantation can occur early (0-100 days) or late (>100 days) post-transplant.  Complications Early bacterial infections, e.g. pseudomembranous colitis fungal infections, often affecting the esophagus or as hepatic/splenic microabscesses ...
Article

Primary bone lymphoma

Primary bone (skeletal/osseous) lymphoma (PBL) is a less common manifestation of lymphoma than secondary involvement from disseminated lymphoma. It is rare, accounting for <5% of bone tumors and <1% of non-Hodgkin lymphoma. Terminology PBL is defined as the presence of lymphoma isolated to one...
Case

Thalassemia - skull

  Diagnosis almost certain
Dalia Ibrahim
Published 13 Jul 2022
77% complete
CT
Case

Gaucher's disease - splenic Gaucheroma

  Diagnosis certain
Liz Silverstone
Published 12 Aug 2021
91% complete
Ultrasound CT Nuclear medicine X-ray
Article

Anemia of chronic disease

Anemia of chronic disease, also known as anemia of inflammation, is a type of anemia caused by chronic inflammation.  Terminology According to some sources, the term 'anemia of inflammation' should replace, or has already replaced, the terms 'anemia of chronic disease' and 'anemia of chronic d...
Case

Multiple myeloma - right proximal femur

  Diagnosis almost certain
Henry Knipe
Published 01 Mar 2022
77% complete
CT
Article

Hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is a multisystem thrombotic microangiopathic disease characterized by the triad of renal failure, hemolytic anemia and thrombocytopenia. It is the most common cause of renal failure in infancy and childhood requiring dialysis.  There are two forms of this syndrom...
Case

Hodgkin lymphoma

  Diagnosis almost certain
James Sheldon
Published 13 Jan 2014
77% complete
CT
Article

Mediastinal lymph node enlargement

Mediastinal lymph node enlargement can occur from a wide range of pathologies and can be isolated or associated with lung pathology. Historically, a size cut-off of 10 mm short-axis diameter was used.  Terminology The term mediastinal lymphadenopathy implies lymph node disease and is not synon...
Case

Anaplastic large cell lymphoma - ALK positive subtype

  Diagnosis almost certain
Ammar Haouimi
Published 09 Jan 2023
77% complete
MRI
Article

AIDS-defining illness

AIDS-defining illnesses are conditions that in the setting of a HIV infection confirm the diagnosis of AIDS and do not commonly occur in immunocompetent individuals 2. According to the CDC surveillance case definition 1, they are: Infectious bacterial infections: multiple or recurrent candidi...
Article

Hyperimmunoglobulin IgE syndrome

Hyperimmunoglobulin E (hyper IgE) syndrome (HIES), also known as Job syndrome, consists of a heterogeneous group of complex hereditary combined B- and T-cell immune deficiency diseases characterized by recurrent Staphylococcus aureus chest infections, characteristic coarse facial appearance and ...
Case

Spontaneous subdural hematomas

  Diagnosis certain
Henry Knipe
Published 10 Oct 2015
87% complete
CT Diagram
Article

Pyrexia of unknown origin

A pyrexia of unknown origin, commonly shortened to PUO, and also known as a fever of unknown origin (FUO), was originally defined in 1961 as the condition in which the core body temperature is >38.3oC for a period of three weeks or more, with no diagnosis reached after one week of inpatient inve...

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