14-3-3 protein

Dr Tim Luijkx and Dr Henry Knipe et al.

14-3-3 protein is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD). 

In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and its specificity is 80% 1. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.

Results need to be correlated with the patient's history as CSF 14-3-3 can be false positive in acute stroke, encephalitis, and other dementias 1.

Share article

Article information

rID: 43597
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Protein 14-3-3
  • 14-3-3 protein in CSF

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.