14-3-3 protein is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD).
In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and the specificity is 80% 1. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.
- 1. Muayqil T, Gronseth G, Camicioli R. Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2012;79 (14): 1499-506. doi:10.1212/WNL.0b013e31826d5fc3 - Free text at pubmed - Pubmed citation
- 2. Vitali P, Maccagnano E, Caverzasi E et-al. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011;76 (20): 1711-9. doi:10.1212/WNL.0b013e31821a4439 - Free text at pubmed - Pubmed citation
- 3. Samson K. Neurology Today. 2012;12 (19): . doi:10.1097/01.NT.0000421885.44638.a9