14-3-3 protein

Dr Craig Hacking and Dr Henry Knipe et al.

14-3-3 protein is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD). 

In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and its specificity is 80% 1. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.

Results need to be correlated with the patient's history as CSF 14-3-3 can be false positive in acute stroke, encephalitis, and other dementias 1.

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Article information

rID: 43597
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Protein 14-3-3
  • 14-3-3 protein in CSF

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