Seven distinct 14-3-3 proteins have been found in humans.
In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and its specificity is 80% 1. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.
History and etymology
The unusual name of the protein family derived from the time of the first protein's discovery when it was found to distribute in the 14th fraction when eluted with DEAE chromatography, and then within fraction 3.3 after additional analysis with gel electrophoresis 4.
- 1. Muayqil T, Gronseth G, Camicioli R. Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2012;79 (14): 1499-506. doi:10.1212/WNL.0b013e31826d5fc3 - Free text at pubmed - Pubmed citation
- 2. Vitali P, Maccagnano E, Caverzasi E et-al. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011;76 (20): 1711-9. doi:10.1212/WNL.0b013e31821a4439 - Free text at pubmed - Pubmed citation
- 3. Samson K. Neurology Today. 2012;12 (19): . doi:10.1097/01.NT.0000421885.44638.a9
- 4. Ralph A. Bradshaw, Edward A. Dennis. Handbook of cell signaling. (2018)