Citation, DOI & article data
Seven distinct 14-3-3 proteins have been found in humans.
In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92%, and its specificity is 80% 1. A negative 14-3-3 assay may help reduce the suspicion of sCJD.
History and etymology
The unusual name of the protein family derived from the time of the first protein's discovery when it was found to distribute in the 14th fraction when eluted with DEAE chromatography, and then within fraction 3.3 after additional analysis with gel electrophoresis 4.
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- 2. Vitali P, Maccagnano E, Caverzasi E et al. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011;76(20):1711-1719. doi:10.1212/wnl.0b013e31821a4439
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- 4. Ralph A. Bradshaw, Edward A. Dennis. Handbook of Cell Signaling. (2009-11-03) ISBN: 9780080920917