Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Anti SRP autoantibody associated interstitial lung disease. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-148840
Anti SRP autoantibody associated interstitial lung disease is a form of autoimmune related interstitial lung disease.
It is thought to usually present with mild respiratory symptoms although some patients have been reported to have severe disease 1.
It is reported to occur as an extraskeletal manifestation of a myopathy such as immune-mediated necrotizing myopathy.
Markers
- anti-SRP antibodies may be elevated.
CT
Reported imaging literature is sparse at time of writing (2022) but with limited reports mostly suggesting an NSIP-type picture 1,2. Some patients have been reported to show an organizing pneumonia-type pattern 2.
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1. Qureshi A, Brown D, Brent L. Anti-Signal Recognition Particle Antibody-Associated Severe Interstitial Lung Disease Requiring Lung Transplantation. Cureus. 2020;12(5):e7962. doi:10.7759/cureus.7962 - Pubmed
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2. Ge Y, Yang H, Xiao X, Liang L, Lu X, Wang G. Interstitial Lung Disease is Not Rare in Immune-Mediated Necrotizing Myopathy with Anti-Signal Recognition Particle Antibodies. BMC Pulm Med. 2022;22(1):14. doi:10.1186/s12890-021-01802-1 - Pubmed
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3. Kusumoto T, Okamori S, Masuzawa K et al. Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-Signal Recognition Particle Antibody. Intern Med. 2018;57(14):2045-9. doi:10.2169/internalmedicine.0303-17 - Pubmed
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4. Kono M, Suda T, Kaida Y, Inui N, Nakamura Y, Chida K. [A Case of Interstitial Pneumonia with Anti-Signal Recognition Particle (SRP) Antibody Without Myopathy]. Nihon Kokyuki Gakkai Zasshi. 2010;48(1):92-7. - Pubmed
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