2-hydroxyglutarate

2-hydroxyglutarate is a metabolite that accumulates in the brains of patients with IDH-1 mutated (IDH-1 positive) brain tumours, particularly diffuse low grade gliomas. Although not in widespread clinical use, it is likely that 2-hydroxyglutarate, which resonates at 2.25 ppm, will be able to be detected in vivo using MR spectroscopy and thus IDH-1 status detected pre-operatively 1. This is important as it is increasingly recognised that IDH-1 status has a significant impact on prognosis. Unfortunately, as it is a small peak, nestled among the GABA and glutamate/glutamine peaks, it requires more advanced MRS techniques and post processing than are currently routinely performed. 


MRI physics
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Article Information

rID: 43878
Section: Physics
Synonyms or Alternate Spellings:
  • 2-hydroxyglutarate peak

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