Pineal parenchymal tumors
Updates to Article Attributes
Body
was changed:
Pineal parenchymal tumours comprise a group of related tumours ranging from the relatively benign to the highly malignant. There are four types5 diagnoses currently recognised in the 5th edition (2021) WHO classification of CNS tumours4:
-
pineocytoma
- 14-30% of pineal parenchymal tumours 2
- mature well-differentiated tumour
- WHO grade
I1
-
pineal parenchymal tumour of indeterminate differentiation
- 20-62% of pineal parenchymal tumours 2
- WHO grade
II/III2 or 3
-
papillary tumour of the pineal region
- yet to be graded but probably equivalent to WHO grade
II/III2 or 3 2
- yet to be graded but probably equivalent to WHO grade
-
pineoblastoma
- 24-50% of pineal parenchymal tumours 2
- malignant, primitive tumours
- WHO grade
IV4
-
desmoplastic myxoid tumour of the pineal region, SMARCB1-mutant
- rare
- only added to 5th edition WHO classification (2021)
As you can tell from the proportions given above, there is wide variation in the reported figures from series to series, which probably reflects the overall rarity of these tumours (and thus small series) and variability in the grading and terminology used.
Terminology
The term pinealoma was historically used to refer to both pineal parenchymal tumorstumours and germinomas 3. This term has since fallen in popularity in the last several decades.
-<p><strong>Pineal parenchymal tumours </strong>comprise a group of related tumours ranging from the relatively benign to the highly malignant. There are four types in the <a href="/articles/who-classification-of-cns-tumours-1">WHO classification</a>:</p><ul>- +<p><strong>Pineal parenchymal tumours </strong>comprise a group of related tumours ranging from relatively benign to highly malignant. There are 5 diagnoses currently recognised in the 5th edition (2021) <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a> <sup>4</sup>:</p><ul>
-<li>WHO grade I</li>- +<li>WHO grade 1</li>
-<li>WHO grade II/III</li>- +<li>WHO grade 2 or 3</li>
-<a href="/articles/papillary-tumour-of-the-pineal-region">papillary tumour of the pineal region</a><ul><li>yet to be graded but probably equivalent to WHO grade II/III <sup>2</sup>- +<a href="/articles/papillary-tumour-of-the-pineal-region">papillary tumour of the pineal region</a><ul><li>yet to be graded but probably equivalent to WHO grade 2 or 3 <sup>2</sup>
-<li>WHO grade IV</li>- +<li>WHO grade 4</li>
-</ul><p>As you can tell from the proportions given above, there is wide variation in the reported figures from series to series, which probably reflects the overall rarity of these tumours (and thus small series) and variability in the grading and terminology used.</p><h4>Terminology</h4><p>The term pinealoma was historically used to refer to both pineal parenchymal tumors and germinomas <sup>3</sup>. This term has since fallen in popularity in the last several decades.</p>- +<li>
- +<a title="Desmoplastic myxoid tumour of the pineal region, SMARCB1-mutant" href="/articles/desmoplastic-myxoid-tumour-of-the-pineal-region-smarcb1-mutant-1">desmoplastic myxoid tumour of the pineal region, SMARCB1-mutant</a><ul>
- +<li>rare</li>
- +<li>only added to 5th edition WHO classification (2021)</li>
- +</ul>
- +</li>
- +</ul><p>As you can tell from the proportions given above, there is wide variation in the reported figures from series to series, which probably reflects the overall rarity of these tumours (and thus small series) and variability in the grading and terminology used.</p><h4>Terminology</h4><p>The term pinealoma was historically used to refer to both pineal parenchymal tumours and germinomas <sup>3</sup>. This term has since fallen in popularity in the last several decades.</p>
References changed:
- 4. Louis D, Perry A, Wesseling P et al. The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary. Neuro-Oncology. 2021;23(8):1231-51. <a href="https://doi.org/10.1093/neuonc/noab106">doi:10.1093/neuonc/noab106</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/34185076">Pubmed</a>