4D syndrome

Changed by Brian Gilcrease-Garcia, 1 Jun 2018

Updates to Article Attributes

Body was changed:

4D syndrome is a term givenused to describe a manifestation of syndromic glucagonomas, a type of pancreatic endocrine tumour.

  • D: dermatitis (necrolytic 2
    • necrolytic migratory erythema - a widespread rash, often involvingtending to involve perioral and perigenital regions
    • oral rashes (angular stomatitis, cheilitis)
    • tend to resolve upon removal of the groin)tumor
  • D: mild diabetes mellitus
  • D: diabetes
  • D: deep vein thrombosis
  • D: depression - may be related to severe chronic dermatosis 2
  • -<p><strong>4D syndrome</strong> is a term given to syndromic <a href="/articles/glucagonoma">glucagonomas</a>, a type of <a href="/articles/endocrine-tumours-of-the-pancreas">pancreatic endocrine tumour</a>.</p><ul>
  • +<p><strong>4D syndrome</strong> is a term used to describe a manifestation of syndromic <a href="/articles/glucagonoma">glucagonomas</a>, a type of <a href="/articles/endocrine-tumours-of-the-pancreas">pancreatic endocrine tumour</a>.</p><ul>
  • -<strong>D: </strong>dermatitis (necrolytic migratory erythema, often involving the groin)</li>
  • +<strong>D: </strong>dermatitis<sup> 2</sup><ul>
  • +<li>necrolytic migratory erythema - a widespread rash, tending to involve perioral and perigenital regions</li>
  • +<li>oral rashes (angular stomatitis, cheilitis)</li>
  • +<li>tend to resolve upon removal of the tumor</li>
  • +</ul>
  • +</li>
  • -<strong>D: </strong>diabetes</li>
  • +<strong>D: </strong>mild diabetes mellitus</li>
  • -<strong>D: </strong><a title="Deep vein thrombosis" href="/articles/deep-vein-thrombosis">deep vein thrombosis</a>
  • +<strong>D: </strong><a href="/articles/deep-vein-thrombosis">deep vein thrombosis</a>
  • -<strong>D: </strong>depression</li>
  • +<strong>D: </strong>depression - may be related to severe chronic dermatosis <sup>2</sup>
  • +</li>

References changed:

  • 2. Feingold K, Anawalt B, Boyce A et al. Glucagonoma Syndrome. 2000. <a href="https://www.ncbi.nlm.nih.gov/pubmed/25905270">PMID 25905270</a>

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