4D syndrome

Changed by Uzaib altaf, 4 May 2021

Updates to Article Attributes

Body was changed:

4D syndrome is a term used to describe a manifestation of syndromic glucagonomas, a type of pancreatic endocrine tumour.

Location:-it’s mostly located in tail of pancreas.

SIZE:-Tumor is malignant ;5-10cm in size .

Characteristic finding in skin:-NME (necrolytic migratory erythema)

  • D: dermatitis 2
    • necrolytic migratory erythema - a widespread rash, tending to involve perioral and perigenital regions
    • oral rashes (angular stomatitis, cheilitis)
    • tend to resolve upon removal of the tumour
  • D: mild diabetes mellitus
  • D: deep vein thrombosis
  • D: depression - may be related to severe chronic dermatosis 2     Conformation of diagnosis :-serum level of glucagon >1000pg/ml.
  • Management:-Surgery is the only option . 
  • -<p><strong>4D syndrome</strong> is a term used to describe a manifestation of syndromic <a href="/articles/glucagonoma">glucagonomas</a>, a type of <a href="/articles/endocrine-tumours-of-the-pancreas">pancreatic endocrine tumour</a>.</p><ul>
  • +<p> <strong>4D syndrome</strong> is a term used to describe a manifestation of syndromic <a href="/articles/glucagonoma">glucagonomas</a>, a type of <a href="/articles/endocrine-tumours-of-the-pancreas">pancreatic endocrine tumour</a>.</p><p><strong>Location</strong>:-it’s mostly located in tail of pancreas.</p><p><strong>SIZE:-</strong>Tumor is malignant ;5-10cm in size .</p><p><strong>Characteristic finding in skin:-</strong>NME (necrolytic migratory erythema)</p><ul>
  • -<strong>D: </strong>depression - may be related to severe chronic dermatosis <sup>2</sup>
  • +<strong>D: </strong>depression - may be related to severe chronic dermatosis <sup>2</sup><strong>   <br>  C<strong>onformation of diagnosis :-serum level of glucagon &gt;1000pg/ml.</strong></strong>
  • +<li><strong><strong>Management:-Surgery is the only option . </strong></strong></li>

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