Citation, DOI, disclosures and article data
Citation:
Rezaee A, Yap J, Rock P, et al. Classification of ductal carcinoma in situ (DCIS). Reference article, Radiopaedia.org (Accessed on 25 Apr 2024) https://radiopaedia.org/articles/45150?iframe=true
The new pathological classification of DCIS (ductal carcinoma in situ) is based on cytonuclear atypia, degree of necrosis, size, and distance from margin/architecture. Low and intermediate grades DCIS require cytologic, architectural and size criteria to be met but high-grade DCIS requires only cytologic criteria; this is as follows:
-
low grade
-
intermediate grade
round, regular to mildly irregular nuclei up to 2-3 times the size of a red blood cell
substantial comedo necrosis
-
high grade
pleomorphic nuclei more than 3 times the size of a red blood cell
substantial comedo necrosis usually present, but not required for the diagnosis
-
1. Pinder SE. Ductal carcinoma in situ (DCIS): pathological features, differential diagnosis, prognostic factors and specimen evaluation. Mod. Pathol.23 Suppl 2: S8-13. doi:doi:10.1038/modpathol.2010.40 - Pubmed citation
-
2. Fadare O, Clement NF, Ghofrani M. High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision. Diagn Pathol. 2009;4 (1): 26. doi:10.1186/1746-1596-4-26 - Free text at pubmed - Pubmed citation
Promoted articles (advertising)