4D syndrome is a term used to describe a manifestation of syndromic glucagonomas, a type of pancreatic endocrine tumor.
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D: dermatitis 2
- necrolytic migratory erythema - a widespread rash, tending to involve perioral and perigenital regions
- oral rashes (angular stomatitis, cheilitis)
- tend to resolve upon removal of the tumor
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D: mild diabetes mellitus
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D: deep vein thrombosis
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D: depression - may be related to severe chronic dermatosis 2
- 1 .Lewis RB, Lattin GE, Paal E. Pancreatic endocrine tumors: radiologic-clinicopathologic correlation. Radiographics. 2010;30 (6): 1445-64. doi:10.1148/rg.306105523 - Pubmed citation
- 2. Vinik A, Pacak K, Feliberti E, et al. Glucagonoma Syndrome. [Updated 2017 Jun 14]. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000.Available free from NCBI - Pubmed citation
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