Widening of the diploic space

Changed by Frank Gaillard, 2 May 2017

Updates to Article Attributes

Title was changed:
Widening of diplocdiploic space
Body was changed:

Widening of diplocdiploic space refers to diffuse, most commonly bilateral, calvarium widening secondary to extra-medullaryextramedullary hematopoiesis within the skull.

Causes

Most commonly caused by systemic underlying pathologies such as:

  • -<p><strong>Widening of diploc space </strong>refers to diffuse, most commonly bilateral, calvarium widening secondary to extra-medullary hematopoiesis within skull.</p><h4><strong>Causes</strong></h4><p>Most commonly caused by systemic underlying pathologies such as:</p><ul>
  • -<li>chronic haemolytic disorders including <a href="/articles/sickle-cell-disease">Sickle cell disease</a>, <a href="/articles/thalassaemia">Thalassaemia</a>, <a href="/articles/iron-deficiency-anaemia">Iron deficiency anaemia</a>  and other chronic severe anaemias. In those cases it may be associated with vertical striations running in diploic space giving rise to characteristic <a href="/articles/hair-on-end-sign-mnemonic">Hair on end sign (mnemonic)</a>. </li>
  • -<li>metabolic disorders including <a href="/articles/renal-osteodystrophy">Renal osteodystrophy</a>, <a href="/articles/hyperparathyroidism">Hyperparathyroidism</a>
  • +<p><strong>Widening of diploic space </strong>refers to diffuse, most commonly bilateral, calvarium widening secondary to extramedullary hematopoiesis within the skull.</p><h4><strong>Causes</strong></h4><p>Most commonly caused by systemic underlying pathologies such as:</p><ul>
  • +<li>chronic haemolytic disorders: may be associated with vertical striations running in diploic space giving rise to the characteristic <a title="Hair on end sign (mnemonic)" href="/articles/hair-on-end-sign-mnemonic">hair on end sign</a>
  • -<li>overgrowth secondary to <a href="/articles/microcephaly">Microcephaly</a> or chronic <a href="/articles/hydrocephalus">Hydrocephalus</a>
  • +<li><ul>
  • +<li><a href="/articles/sickle-cell-disease">sickle cell disease</a></li>
  • +<li><a href="/articles/thalassaemia">thalassaemia</a></li>
  • +<li><a title="Iron deficiency anaemia" href="/articles/iron-deficiency-anaemia">iron deficiency anaemia</a></li>
  • +<li>and other chronic severe anaemias</li>
  • +</ul></li>
  • +<li>metabolic disorders<ul>
  • +<li><a href="/articles/renal-osteodystrophy">renal osteodystrophy</a></li>
  • +<li><a href="/articles/hyperparathyroidism">hyperparathyroidism</a></li>
  • +</ul>
  • -<li>medication including Phenytoin <a href="/articles/phenytoin-cerebellar-degeneration">Phenytoin cerebellar degeneration</a>
  • +<li>overgrowth<ul><li><a href="/articles/microcephaly">microcephaly</a></li></ul>
  • +</li>
  • +<li>medication<ul><li>phenytoin</li></ul>

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