Citation, DOI, disclosures and article data
Citation:
Iqbal S, Sharma R, Bell D, et al. Neuroendocrine carcinoma of the cervix. Reference article, Radiopaedia.org (Accessed on 23 Apr 2024) https://doi.org/10.53347/rID-87891
Neuroendocrine carcinoma of the cervix is a rare type of invasive cervical cancer. These are very aggressive tumors with rapid lymph nodal metastasis 1,2.
Neuroendocrine carcinomas of the cervix account for approximately ~2% of tumors of the cervix seen in the females of reproductive age group 1,2. Neuroendocrine tumors of the cervix are related to human papillomavirus type 18.
Classification
Neuroendocrine carcinomas of the cervix may be classified into small cell, large cell, and other types (which are rare) which include carcinoid, and atypical carcinoid tumor.
Treatment and prognosis
In line with the aggressive nature of neuroendocrine tumors, a multimodality approach of a chemotherapeutic regimen of etoposide and cisplatin, and in cases of recurrent disease topotecan, paclitaxel, and bevacizumab followed by radiation and radical surgery may be included in treatment. The prognosis of this carcinoma is very poor with mean survival is up to ~36 months 3-5.
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5. Gardner G, Gardner RLD, Gardner GP, Gardner. Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. (2011) Gynecologic oncology. doi:10.1016/j.ygyno.2011.04.011 - Pubmed
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6. Hillman RT, Cardnell R, Fujimoto J, Lee WC, Zhang J, Byers LA, Ramalingam P, Leitao M, Swisher E, Futreal PA, Frumovitz M. Comparative genomics of high grade neuroendocrine carcinoma of the cervix. (2020) PloS one. 15 (6): e0234505. doi:10.1371/journal.pone.0234505 - Pubmed
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