Acute lung injury
Updates to Article Attributes
Body
was changed:
Acute lung injury (ALI) refers to a rather broad clinical syndrome defined by a constellation of clinical criteria which includes:
- acute onset of bilateral pulmonary infiltrates
- with hypoxaemia
- without evidence of hydrostatic pulmonary oedema
- pulmonary wedge pressures of usually 18 mmHg or less
.
It encompasses and also carries some overlap with the term acute respiratory distress syndrome (ARDS) with some publications stating a PaO2/FiO2 of:
- ≤300 for ALI 1
- ≤200 for ARDS 1
Some publications state ARDS as a more severe form of ALI.
Pathology
Histologically, it is represented by diffuse alveolar damage in most cases but can also be uncommonly be represented by acute eosinophilic pneumonia (AEP) and acute fibrinous and organising pneumonia (AFOP) 6. It can be precipitated by numerous agents.
Treatment and prognosis
Treatment is primarily supportive through supplemental oxygen with mechanical ventilation provided if necessary. The prognosis is variable.
-<li>pulmonary wedge pressures usually 18 mmHg or less. </li>- +<li>pulmonary wedge pressures of usually 18 mmHg or less</li>
-</ul><p>Some publications state ARDS as a more severe form of ALI.</p><h4>Pathology</h4><p>Histologically, it is represented by <a href="/articles/diffuse-alveolar-damage">diffuse alveolar damage</a> in most cases but can also be uncommonly be represented by <a href="/articles/acute-eosinophilic-pneumonia">acute eosinophilic pneumonia (AEP)</a> and <a href="/articles/acute-fibrinous-and-organising-pneumonia">acute fibrinous and organising pneumonia (AFOP)</a> <sup>6</sup>. It can be precipitated by numerous agents.</p><h4>Treatment and prognosis</h4><p>Treatment is primarily supportive through supplemental oxygen with mechanical ventilation provided if necessary. The prognosis is variable.</p>- +</ul><p>Some publications state ARDS as a more severe form of ALI.</p><h4>Pathology</h4><p>Histologically, it is represented by <a href="/articles/diffuse-alveolar-damage">diffuse alveolar damage</a> in most cases but can also be uncommonly represented by <a href="/articles/acute-eosinophilic-pneumonia">acute eosinophilic pneumonia (AEP)</a> and <a href="/articles/acute-fibrinous-and-organising-pneumonia">acute fibrinous and organising pneumonia (AFOP)</a> <sup>6</sup>. It can be precipitated by numerous agents.</p><h4>Treatment and prognosis</h4><p>Treatment is primarily supportive through supplemental oxygen with mechanical ventilation provided if necessary. The prognosis is variable.</p>
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