The abscopal effect is a term used in oncology which refers to a phenomenon in which a locoregional therapy for a tumor leads to systemic anti-tumor effects, such as shrinkage of distant (non-target) tumors.
While the precise mechanism(s) of action are not fully understood, there is a growing area of basic science research investigating this occurrence and it is believed the effect is due to the recruitment of the immune system.
The abscopal effect has commonly been reported after external beam radiotherapy. In interventional oncology, there are scarce case report data of abscopal effects following techniques such as brachytherapy and transarterial radioembolization (TARE) or radiofrequency ablation (RFA) of tumors.
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