Acinar-predominant adenocarcinoma of the lung

Last revised by Daniel J Bell on 21 May 2020

Acinar-predominant adenocarcinoma of the lung is a histological subtype of non-mucinous invasive adenocarcinoma of the lung.


In 2011, the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) 4 introduced a new classification and terminology for adenocarcinoma of the lung, which is now divided into 'preinvasive', 'minimally invasive', and 'invasive'. 

The term bronchoalveolar carcinoma (BAC) has been retired, and it is recommended that all invasive adenocarcinomas be classified in terms of the "predominant" comprising histology 4. Both mucinous and non-mucinous adenocarcinomas typically consist of a mixture of histologic patterns, but reporting of the predominant subtype (lepidic, acinar, papillary, micropapillary, or solid growth) is specifically recommended for non-mucinous lesions, with all mucinous tumors placed in a separate category.

Treatment and prognosis

Acinar patterns are thought to have an intermediate prognosis but better than those associated with micropapillary, mucinous/colloid, and solid patterns and worse than those with lepidic predominant patterns 1,3

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