Acquired lipodystrophy

Acquired lipodystrophy is defined by loss of body fat, insulin resistance and metabolic profile derangement. Subtypes include Barraquer-Simons syndrome, localized lipodystrophy, and Lawrence syndrome.  Lipodystrophy is illustrated as a complete or partial loss of adipose tissues from the body. 

Overactivation of the complement system has been documented in most of the cases with acquired lipodystrophy 4. The condition is often seen in patients on certain medications incuding HAART therapy for HIV disease but also can be seen in some autoimmune patients or may be idiopathic.

Whole-body MR is a modality of preference to see the pattern of fat loss in acquired lipodystrophy.

A multidisciplinary strategy with sufficient counseling, metreleptin (recombinant leptin) 6, symptomatic treatment and address of primary disease are a mainstay of therapy. 

Article information

rID: 80591
Section: Pathology
Synonyms or Alternate Spellings:

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