Last revised by Alice Willison on 25 Aug 2019

Acrocephalosyndactyly syndromes (ACS) are a rare group of disorders collectively characterized by:


While there can be some overlap in features, they can be primarily classified into the following major types:

When there are calvarial anomalies with polydactyly and syndactyly, these then fall into group named acrocephalopolysyndactyly syndromes (ACPS). However, many suggest that the distinction between ACS and ACPS should be abandoned ref.

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Cases and figures

  • Case 1: Apert syndrome
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