Last revised by Fathima Raeesa on 13 Mar 2021

Acromegaly is the result of excessive growth hormone production in skeletally mature patients, most commonly from a pituitary adenoma. The same excess of growth hormone in individuals whose epiphyses have not fused will result in gigantism (excessively tall stature).  

Acromegaly is most commonly diagnosed in middle-aged adults and can result in severe disfigurement, serious complicating conditions, and premature death. It has both an insidious onset and slow progression and may be difficult to diagnose in the early stages, only being diagnosed when the external features, especially those of the face, become noticeable.

Clinical presentation is often with a variety of relatively non-specific symptoms or medical problems. These include: 

In contrast, examination of the patient will often reveal a very characteristic constellation of physical signs:

  • overgrowth
  • skin changes
    • hypertrichosis
    • hyperpigmentation
    • hyperhidrosis

Typically cases show elevated levels of:

  • growth hormone
  • IGF-1 (insulin-like growth factor 1)

Approximately 95% of cases are the result of a pituitary adenoma 10. The remaining 5% of cases are the result of other tumors of the pancreas, lungs, or adrenal glands that release growth hormone. A very small number of cases result from the excessive use of exogenous growth hormone in athletes. 

Calvarial thickening, particularly of the inner table 10, frontal bossing, enlarged paranasal sinuses (especially frontal sinuses) and an enlarged sella turcica.

The mandible also characteristically enlarges resulting in prognathism and gaps between the teeth 10. This appearance is sometimes referred to as a "lantern jaw" 11 although this is merely a descriptive term, not unique to acromegaly. 

Evidence of vertebral body fractures, most commonly in the thoracolumbar region lead researchers to recently state that radiographic screening of this region is indicated 4. Vertebral fracture without loss of bone mineral density is related to increased bone turnover markers seen in acromegaly 4. Other features seen in the spine include a DISH-like appearance, posterior vertebral scalloping, increased vertebral height, elongation and widening of the vertebral bodies.

Vertebral body anteroposterior and transverse diameter increase, due to subperiosteal bone deposition increase can also lead to platyspondyly.

Joints will show the typical patterns of osteoarthritis, and will continue to deteriorate even after biochemical remission is achieved, which is why it is prudent in the clinical setting to monitor the progression of "acromegalic arthropathy" 6,7. There has also been a reported higher incidence of crystal deposition disease.

Terminal phalangeal tufts become hypertrophied and have a "spade appearance", which is called the spade phalanx sign. Joint spaces may be minimally enlarged. Premature osteoarthritis can occur in the advanced stages of acromegaly.

Heel pad thickness may be increased (>25 mm).

Three steps of acromegalic cardiomyopathy have been described 9:

  • early phase (reversible): initial cardiac hypertrophy, increased heart rate and systolic output, defined as the hyperkinetic syndrome
  • middle phase of untreated or uncontrolled disease: cardiac hypertrophy with signs of diastolic dysfunction
  • end-stage of untreated disease (not reversible): dilated cardiomyopathy

Other joints may show ligamentous and cartilaginous hypertrophy, and crystal deposition 7.

Enlarged pituitary with increased gadolinium uptake. The MRI diagnosis of a pituitary macroadenoma is relatively straightforward. Dynamic contrast-enhanced MRI increases the sensitivity for detecting microadenomas. Microadenomas are hypoenhancing compared to the normal pituitary gland.

Hypertrophy of spinal ligaments and cartilaginous structures and features of osteoarthritis 7.

The treatment of choice is resection of the secreting adenoma, usually via the transsphenoidal approach. Alternatively, especially in surgically-refractory cases, treatment is with a primary somatostatin receptor ligand, with or without concomitant growth hormone receptor antagonist therapy 3. Radiation therapy is also used in medical circumstances where other therapies have not been able to control tumor size, growth and production of excess growth hormone. The most frequently used radiation therapy for acromegaly is Gamma Knife, with more traditional techniques, including image-guided radiation therapy, associated with increased risk of cerebrovascular mortality.

The severity of symptoms and comorbidities for acromegaly patients is directly related to the level of elevated hormone as well as length of time that the patient was exposed to a high level versus a high-normal, or normal level, making identification and proper diagnosis of great importance 4,6,7. Mortality rates can decrease to those of the general population if appropriate diagnosis and treatment are achieved to normalize serum growth hormone and IGF-1 levels 5.

The word "acromégalie" was coined by the French neurologist Pierre Marie in 1886. He created the word from the Greek words ακρος (akros) which means "summit, extremity" and μεγαλως (megalos), an adverbial form derived from μεγας (megas) meaning "great" 13-15.

Marie was not the first to describe a case though, that honor falls to Andrea Verga, an Italian neurologist and psychiatrist, who wrote up a patient he saw in 1864. He named the condition “prosopo-ectasia”, which means widening of the face. At this lady's autopsy he discovered a grape-sized tumor within the pituitary fossa and no normal pituitary gland 13.

In 2011 an AIP (aryl hydrocarbon-interacting protein gene) mutation was linked to acromegalic gigantism, found when studying four Irish families who displayed acromegalic and gigantism traits, known as childhood-onset acromegaly (i.e. when a child has gigantism which progresses through adulthood to acromegaly). It is said that there could be hundreds of carriers of this mutant gene, leading researchers to suggest that all childhood-onset acromegaly patients, especially those who have a family history of pituitary adenoma or acromegaly, should be screened and followed 8.

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Cases and figures

  • Figure 1: acromegaly with prognathism
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  • Case 1
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  • Figure 2: acromegalic hands
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  • Case 2
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  • Figure 3: acromegalic facies
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  • Case 3
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  • Case 4
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  • Case 4: increased heel pad thickness
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