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Citation:
Weerakkody Y, Feger J, Acute erythroid leukemia. Reference article, Radiopaedia.org (Accessed on 11 Oct 2024) https://doi.org/10.53347/rID-191772
Acute erythroid leukemia (AML-M6 or AEL) is a subtype of acute myeloid leukemia (AML) with a predominance of erythroid precursors.
This type accounts for less than 5% of all cases of acute myeloid leukemia 1.
The diagnosis is histological.
According to the World Health Organization (WHO), a biopsy sample with ≥30% proerythroblasts and erythroid precursors accounting for ≥80% of cellularity is required to make a diagnosis 2.
Subtypes
This can be divided into two morphologic categories:
erythroleukemia (M6a), consisting of myeloblasts and erythroid precursors
pure erythroid leukemia (M6b)
erythroleukemia and pure erythroid leukemia (M6c): myeloblast- and proerythroblast-rich mixed variant.
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1. Zuo Z, Polski J, Kasyan A, Medeiros L. Acute Erythroid Leukemia. Arch Pathol Lab Med. 2010;134(9):1261-70. doi:10.5858/2009-0350-RA.1 - Pubmed
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2. Fernandes P, Waldron N, Chatzilygeroudi T, Naji N, Karantanos T. Acute Erythroid Leukemia: From Molecular Biology to Clinical Outcomes. Int J Mol Sci. 2024;25(11):6256. doi:10.3390/ijms25116256 - Pubmed
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3. Ferreira C, Lima F, Goto E et al. Acute Erythroid Leukemia: Autopsy Report of a Rare Disease. Autops Case Rep. 2011;1(4):11-20. doi:10.4322/acr.2011.012 - Pubmed
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4. Reichard K, Tefferi A, Abdelmagid M et al. Pure (Acute) Erythroid Leukemia: Morphology, Immunophenotype, Cytogenetics, Mutations, Treatment Details, and Survival Data Among 41 Mayo Clinic Cases. Blood Cancer J. 2022;12(11):147. doi:10.1038/s41408-022-00746-x - Pubmed
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