Acute leukoencephalopathy with restricted diffusion (ALERD) is a clinicoradiological spectrum of disease with clinical features of leukoencephalopathy and associated imaging findings where diffusion restriction is the dominant finding.
Radiographic features
The dominant radiological feature is diffusion restriction, predominantly in the subcortical white matter. Imaging in the first 48-72 hours following symptoms onset is usually normal and is followed by subcortical diffusion restriction between the 3rd and 9th day following symptom onset 1.
See also
acute encephalopathy
acute encephalopathy with biphasic seizures and late reduced diffusion
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