Acute lung injury (ALI) refers to a rather broad clinical syndrome defined by a constellation of clinical criteria which includes:
- acute onset of bilateral pulmonary infiltrates
- with hypoxemia
- without evidence of hydrostatic pulmonary edema
- pulmonary wedge pressures usually 18 mmHg or less.
- ≤300 for ALI 1
- ≤200 for ARDS 1
Some publications state ARDS as a more severe form of ALI.
Histologically, it is represented by diffuse alveolar damage in most bases but can also be uncommonly be represented by acute eosinophilic pneumonia (AEP) and acute fibrinous and organizing pneumonia (AFOP) 6. It can be precipitated by numerous agents.
Treatment and prognosis
Treatment is primarily supportive through supplemental oxygen with mechanical ventilation provided if necessary. The prognosis can be variable.
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