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Acute lung transplant rejection

Acute lung transplant rejection is one of the early post lung transplant complications.

It can occur as several episodes and the first episode may occur early as 5 days after transplantation. The incidence is thought to peak at approximately 2 months post-transplantation (with several episodes occurring) 3. After 6 months, acute rejection is an uncommon event.

Histologically, it is defined as perivascular or peribronchiolar mononuclear inflammation and may affect up to 55% of lung transplant recipients within the first year after a transplant 2

While no single individual CT finding can be specific to the diagnosis 4,8, CT may show:

Radiographic features may show a dramatic response to steroid therapy 5,8.

Acute lung rejection can be further complicated by the subsequent development of bronchiolitis obliterans syndrome (BOS) which is a condition of progressive airflow obstruction that limits survival to only 50% at 5 years post-transplantation 2.

Radiographic appearances can mimic 6:

Article information

rID: 26053
System: Chest
Tag: cases, refs
Synonyms or Alternate Spellings:
  • Acute pulmonary rejection
  • Acute pulmonary allograft rejection
  • Acute lung allograft rejection

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