Acute motor axonal neuropathy

Last revised by Daniel J Bell ◉ on 12 Nov 2021

Citation, DOI, disclosures and article data

Citation:

Jindani I, Bell D, Luong D, et al. Acute motor axonal neuropathy. Reference article, Radiopaedia.org (Accessed on 24 Mar 2023) https://doi.org/10.53347/rID-12316

DOI:

https://doi.org/10.53347/rID-12316

Permalink:

https://radiopaedia.org/articles/12316

rID:

12316

Article created:

10 Nov 2010, Imran Jindani

Disclosures:

At the time the article was created Imran Jindani had no recorded disclosures.

View Imran Jindani's current disclosures

Last revised:

12 Nov 2021, Daniel J Bell ◉

Disclosures:

At the time the article was last revised Daniel J Bell had no recorded disclosures.

View Daniel J Bell's current disclosures

Revisions:

14 times, by 7 contributors - see full revision history and disclosures

Systems:

Central Nervous System

Sections:

Syndromes

Tags:

stub, refs, syndrome

Synonyms:

Acute motor axonal neuropathy (AMAN)
Chinese paralytic syndrome

Acute motor axonal neuropathy (AMAN) is characterized as progressive symmetrical flaccid paralysis with areflexia. It is a pure motor axonopathy and is a variant of Guillain-Barré syndrome.

Terminology

In 1991, a short-lived epidemic of Guillain-Barré syndrome (GBS) was seen in Northern China. This gave rise to the short-lived and historical synonym "Chinese paralytic syndrome" for what was felt to be a form of acute motor axonal neuropathy, a distinct subtype of GBS. However studies showed that ³:

sensory symptoms and signs played a larger part than was originally reported; this conclusion was supported by electrophysiological studies showing demyelination of sensory, as well as motor, fibers
the clinical presentation was typical Guillain-Barré syndrome, therefore a separate monicker, i.e. Chinese paralytic syndrome, was unnecessary and therefore inappropriate

There are no articles published after 1996 in the medical literature using this term.