Acute promyelocytic leukaemia (APML) is a distinct subtype of acute myeloid leukaemia.
Pathology
Genetics
It is defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukaemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha gene (RARα) on chromosome 17.
Treatment and prognosis
Complications
History and etymology
It was first described as a distinct entity in 1957.