Acute promyelocytic leukemia

Acute promyelocytic leukemia (APML) is a distinct subtype of acute myeloid leukemia.

Pathology

Genetics

It is defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17.

History and etymology

It was first described as a distinct entity in 1957.

Related complications

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Article information

rID: 61061
System: Haematology
Synonyms or Alternate Spellings:
  • APML
  • Acute promyelocytic leukemia (APML)

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