Acute respiratory distress syndrome
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Acute respiratory distress syndrome (ARDS) is a form of acute lung injury and occurs as a result of a severe pulmonary injury that causes alveolar damage heterogeneously throughout the lung. It can either result from a direct pulmonary source or as a response to systemic injury.
This is a distinct entity from neonatal respiratory distress syndrome, which is caused by surfactant deficiency in premature babies.
ARDS has a similar clinical presentation and histological features to those seen in acute interstitial pneumonitis (AIP), showing extensive diffuse alveolar damage (DAD). Both conditions likely represent the same pathology, with AIP probably accounting for some of the idiopathic cases of ARDS.
Lung damage results in leakage of fluid into alveoli, leading to non-cardiogenic pulmonary edema and decreased arterial oxygenation.
The diagnosis is based on mainly clinical criteria set forth by the American-European Consensus Conference 4. Acute respiratory distress syndrome is characterized by the following criteria 7:
lung injury of acute onset, within one week of an apparent clinical insult and with the progression of respiratory symptoms
respiratory failure not explained by heart failure or volume overload
decreased arterial PaO2/FiO2 ratio
mild ARDS: 201-300
moderate ARDS: 101-200
severe ARDS: ≤100
It is of note that the clinical diagnosis of ARDS using internationally accepted guidelines and chest radiographs has been demonstrated to correlate poorly with histopathological diagnosis at autopsy 8,9.
The causes of ARDS can result from a direct lung injury, termed pulmonary ARDS, or extrapulmonary where the triggering insult is outside of the lungs. These two etiological subtypes respond in different ways to mechanical ventilation. Some authors have described distinct early phase radiological appearances between the two.
pulmonary irritants 16
chlorine, chloramines, ammonia
oxides of nitrogen
transfusion-related lung injury (TRALI)
systemic toxicologic exposures
colchicine, amiodarone, salicylates
opioids, sedative-hypnotics, cocaine
Chest radiographic findings of acute respiratory distress syndrome are non-specific and resemble those of typical pulmonary edema or pulmonary hemorrhage. There are diffuse bilateral coalescent opacities (the only radiological criterion defined by the Consensus Conference). The time course of ARDS may help in differentiating it from typical pulmonary edema.
Chest x-ray features usually develop 12-24 hours after initial lung insult as a result of proteinaceous interstitial edema. Within one week, alveolar pulmonary edema (hyaline membrane) occurs due to type 1 pneumocyte damage.
In contrast to cardiogenic pulmonary edema, which clears in response to diuretic therapy, ARDS persists for days to weeks. Also, as the initial radiographic findings of ARDS clear, the underlying lung appears to have a reticular pattern secondary to type 2 pneumocyte proliferation and fibrosis 4.
Features depend on the phase of the disease 10.
pulmonary opacification: often demonstrates an anteroposterior density gradient within the lung, with dense consolidation in the most dependent regions, merging into a background of widespread ground-glass attenuation and then normal or hyperexpanded lung in the non-dependent regions (described as a classical appearance 10)
the typical CT presentation of bilateral symmetrical changes is more common in extrapulmonary ARDS, whereas in pulmonary ARDS the opacities tend to be asymmetrical 11
ground-glass opacification: a non-specific sign that reflects an overall reduction in the air content of the affected lung. In acute ARDS likely represent edema and protein within the interstitial and alveolar spaces
bronchial dilatation within areas of ground-glass opacification
some publications also report pulmonary cysts in the early phase 11
Postulated reason for inhomogeneity of appearances:
increased weight of overlying lung causing compressive atelectasis posteriorly, which produces dense opacification
supported by the fact that with the positional change from supine to prone, the density gradient can quickly redistribute accordingly
In the non-dependent portions, the lung may be of normal attenuation, or it may be lower if mechanically ventilated.
Late phase and appearances in long-term survivors
CT appearances can be variable in this phase:
complete resolution: may occur in some cases
coarse reticular pattern and ground-glass opacification in the anterior (non-dependent) part of the lungs: considered more typical later-stage CT appearances
areas of reticular and ground-glass opacification
pulmonary cysts of varying sizes and bullae (probably develop as a result of prolonged ventilation)
One described method is the Ichikado CT scoring of acute respiratory distress syndrome.
Point of care ultrasound may be used to complement more traditional imaging modalities to differentiate cardiogenic from non-cardiogenic pulmonary edema, as well as potentially assess dynamic responses to therapy (e.g. recruitment maneuvers, ventilator changes) at bedside.
Sonographic findings consistent with a diagnosis of ARDS include:
defined by the presence of bilateral, diffuse lung rockets 19
three or more B-lines per intercostal sonographic field
interposed "spared areas" of normal sonographic lung
commonly more prominent in anterior fields
pleural interface abnormalities
absence of significant pleural effusions
common in cardiogenic pulmonary edema
absence of elevated cardiac filling pressures 17
Treatment and prognosis
Acute respiratory distress syndrome carries high mortality of around 50% 2 and many survivors develop chronic lung disease, with the damaged lung healing by fibrosis. However, a minority do make a full recovery.
History and etymology
It was first described in 1967 by Dave G Ashbough (fl. 2019) et al 13.