Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Knipe H, Bell D, et al. Adalimumab-induced interstitial lung disease. Reference article, Radiopaedia.org (Accessed on 20 Apr 2024) https://doi.org/10.53347/rID-89264
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Adalimumab-induced interstitial lung disease is a form of anti-TNF-induced diffuse interstitial lung disease from the broader category of drug-induced lung disease. The disease occurs as a response to the disease-modifying anti-rheumatic drug (DMARD), adalimumab.
Pathology
The exact mechanism of pulmonary toxicity is unclear with one thought being the inhibition of inflammatory cells by anti-TNF drugs leading to unopposed activity of inflammatory cells resulting in characteristic changes of interstitial pneumonitis.
The form of lung injury can vary from acute lung injury (ALI) 2 to pulmonary fibrosis 3,4.
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