Adalimumab induced interstitial lung disease

Adalimumab induced interstitial lung disease is a form of anti-TNF-induced diffuse interstitial lung disease which from under the broader category of drug induced lung disease which occurs as a response to the disease modifying anti-rheumatic drug adalimumab or HumiraTM.

Pathology

Exact mechanism of pulmonary toxicity unclear with one thought being inhibition of inflammatory cells by anti-TNF drugs leading to unopposed activity of inflammatory cells resulting in characteristic changes of an interstitial pneumonitis. 

The from of lung injury can vary from acute lung injury (ALI) 2 to pulmonary fibrosis 3-4.

Article information

rID: 89264
System: Chest
Synonyms or Alternate Spellings:
  • Humira associated interstitial lung disease
  • Adalimumab associated interstitial lung disease
  • Adalimumab related interstitial lung disease

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