Adenocarcinoma of the appendix, also referred to as nonmucinous adenocarcinoma of the appendix, is an uncommon type of appendiceal epithelial neoplasm. Different from the appendiceal mucinous neoplasms, these tumours share similar epidemiology and pathology with colorectal adenocarcinoma.
As colorectal cancer, these tumours commonly occur in elderly patients, often in the 6th decade of life 1.
These tumours differ from polyps and adenomas, which are confined to the mucosal layer and do not invade the muscularis mucosae but are thought to arise from adenomas in virtually all cases 2. They are classified as well, moderately, and poorly differentiated 1.
Cross-sectional imaging usually shows an ill-defined soft tissue mass in the appendix, which can invade adjacent structures 3.
The appearance of appendiceal adenocarcinoma with early obstruction is typically that of appendicitis, consisting of a thickened, inflamed appendix with non-filling with contrast material and periappendiceal fat stranding 2-3.
- 1. Leonards LM, Pahwa A, Patel MK, Petersen J, Nguyen MJ, Jude CM. Neoplasms of the Appendix: Pictorial Review with Clinical and Pathologic Correlation. Radiographics : a review publication of the Radiological Society of North America, Inc. 37 (4): 1059-1083. doi:10.1148/rg.2017160150 - Pubmed
- 2. James L. Abbruzzese. Gastrointestinal Oncology. ISBN: 9780195133721
- 3. Angela D. Levy, Koenraad J. Mortele, Benjamin M. Yeh. Gastrointestinal Imaging. ISBN: 9780199759422
The appendix can be affected by numerous inflammatory, infectious and neoplastic conditions:
- appendiceal mucocele
- appendiceal intussusception
neoplasms of the appendix
- appendiceal epithelial neoplasms
- Goblet cell carcinoid of the appendix
- appendiceal neuroendocrine tumours
- appendiceal lymphoma