Adenomyomatosis of the gallbladder

Adenomyomatosis of the gallbladder is a hyperplastic cholecystosis of the gallbladder wall. It is a relatively common and benign cause of diffuse or focal gallbladder wall thickening. It is most easily seen on ultrasound and MRI. 

Adenomyomatosis is relatively common, found in ~9% of all cholecystectomy specimens 5. It is typically seen in patients in their 5th decade. The incidence increases with age, presumably the result of protracted inflammation (see below). There is a female predilection (M:F=1:3).

It is most often an incidental finding and usually requires no treatment. It may be found more often in chronically inflamed gallbladders (which are at higher risk for carcinoma), but it is not a premalignant lesion in itself 5.

Adenomyomatosis per se is usually asymptomatic. It is, however, frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%), but also seen in cholesterolosis (33%) and pancreatitis 2.

Adenomyomatosis is one of the hyperplastic cholecystoses. There is hyperplasia of the wall with the formation of Rokitansky-Aschoff sinuses (intramural diverticula lined by mucosal epithelium) penetrating into the muscular wall of the gallbladder, with or without gallbladder wall thickening. Cholesterol accumulation in adenomyomatosis is intraluminal, as cholesterol crystals precipitate in the bile trapped in Rokitansky-Aschoff sinuses.

Three morphological types of adenomyomatosis are described:

  • fundal (localised)
  • segmental (annular)
  • generalised (diffuse)
  • mural thickening (diffuse, focal, annular)
  • comet-tail artefact: echogenic intramural foci from which emanate V-shaped comet tail reverberation artefacts are highly specific for adenomyomatosis, representing the unique acoustic signature of cholesterol crystals within the lumina of Rokitansky-Aschoff sinuses 4
  • abnormal gallbladder wall thickening and enhancement are common but nonspecific CT features of adenomyomatosis
  • Rokitansky-Aschoff sinuses of sufficient size can be visualised; a CT rosary sign has been described, formed by enhancing epithelium within intramural diverticula surrounded by the relatively unenhanced hypertrophied gallbladder muscularis

Historically, oral cholecystograms were performed; however, due to low sensitivity and a high rate of contrast hypersensitivity, they have now been largely replaced by MRCP which does not rely on contrast opacification of the gallabladder lumen. MRCP is also able to detect:

  • mural thickening
  • focal sessile mass
  • fluid filled intramural diverticula (pearl necklace sign)
  • hourglass configuration in annular types
  • pearl necklace sign refers to the characteristically curvilinear arrangement of multiple rounded hyperintense intraluminal cavities visualised on T2-weighted MR imaging and MRCP  4
  • FDG-PET
    • metabolic characterisation with PET has been suggested as a useful adjunct in problematic cases 4, but there have also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results 6

Cholecystectomy may be performed as a result of one or more of the following:

  • patient symptomatic with right upper quadrant pain (often due to gallstones)
  • appearances (especially when focal) may be difficult to distinguish from malignancy

General imaging differential considerations include:

Exclusion of gallbladder cancer may be most problematic in segmental and focal cases. Focal adenomyomatosis may appear as a discrete mass, known as an adenomyoma.

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Article information

rID: 7056
Synonyms or Alternate Spellings:
  • Adenomyomatous hyperplasia of the gallbladder
  • Adenomyomatosis of gallbladder
  • Gallbladder adenomyomatosis
  • Adenomyomatosis involving the gallbladder

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Cases and figures

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    Figure 1: adenomyomatosis
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    Case 1
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    Case 2: fundal
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    Case 6: with rosary sign
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    Case 11: segmental adenomyomatosis
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    Case 13: with comet tail artefact
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    Case 14: fundal localised type
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