Adenomyomatosis of the gallbladder

Last revised by Andrea Molinari on 15 Mar 2023

Adenomyomatosis of the gallbladder is a hyperplastic cholecystosis of the gallbladder wall. It is a relatively common and benign cause of diffuse or focal gallbladder wall thickening, most easily seen on ultrasound and MRI. 

Adenomyomatosis is relatively common, found in ~9% of all cholecystectomy specimens 6. It is typically seen in patients in their 5th decade. The incidence increases with age, presumably the result of protracted inflammation (see below). There is a female predilection (M:F=1:3).

It is most often an incidental finding and usually requires no treatment. It may be found more often in chronically inflamed gallbladders (which are at higher risk for carcinoma), but it is not a premalignant lesion in itself 6.

Adenomyomatosis per se is usually asymptomatic. It is, however, frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%), but also seen in cholesterolosis (33%) and pancreatitis 2.

Adenomyomatosis is one of the hyperplastic cholecystoses. There is hyperplasia of the wall with the formation of Rokitansky-Aschoff sinuses (intramural diverticula lined by mucosal epithelium) penetrating into the muscular wall of the gallbladder, with or without gallbladder wall thickening. Cholesterol accumulation in adenomyomatosis is intraluminal, as cholesterol crystals precipitate in the bile trapped in Rokitansky-Aschoff sinuses.

Three morphological types of adenomyomatosis are described:

  • fundal (localized)
  • segmental (annular)
  • generalized (diffuse)
  • mural thickening (diffuse, focal, annular)
  • comet-tail artifact: echogenic intramural foci from which emanate V-shaped comet tail reverberation artifacts are highly specific for adenomyomatosis, representing the unique acoustic signature of cholesterol crystals within the lumina of Rokitansky-Aschoff sinuses 4
  • abnormal gallbladder wall thickening and enhancement are common but non-specific CT features of adenomyomatosis
  • Rokitansky-Aschoff sinuses of sufficient size can be visualized; a CT rosary sign has been described, formed by enhancing epithelium within intramural diverticula surrounded by the relatively unenhanced hypertrophied gallbladder muscularis

MRCP is the technique usually employed for the gallbladder and biliary tree characterization. Imaging features include:

  • mural thickening
  • focal sessile mass
  • fluid-filled intramural diverticula
    • pearl necklace sign refers to the characteristically curvilinear arrangement of multiple rounded hyperintense intramural cavities visualized on T2-weighted MR imaging and MRCP 4
  • hourglass configuration in annular types 5

Metabolic characterization with FDG PET has been suggested as a useful adjunct in problematic cases 4, but there have also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results 7

Cholecystectomy may be performed as a result of one or more of the following:

  • patient symptomatic with right upper quadrant pain (often due to gallstones)
  • appearances (especially when focal) may be difficult to distinguish from malignancy

General imaging differential considerations include:

Exclusion of gallbladder cancer may be most problematic in segmental and focal cases. Focal adenomyomatosis may appear as a discrete mass, known as an adenomyoma.

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Cases and figures

  • Figure 1: adenomyomatosis
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  • Figure 2: histology
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  • Case 1
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  • Case 2: fundal
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  • Case 3
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  • Case 4
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  • Case 5
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  • Case 6: with rosary sign
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  • Case 7
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  • Case 8
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  • Case 9
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  • Case 10
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  • Case 11: segmental adenomyomatosis
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  • Case 12
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  • Case 13: with comet tail artefact
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  • Case 14: fundal localized type
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  • Case 15
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  • Case 16
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  • Case 17: cholesterolosis and adenomyomatosis
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  • Case 18: with chronic pancreatitis - pancreatic duct calculi
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  • Case 19: annular type
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  • Case 20
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