Adenosquamous carcinoma of lung
Citation, DOI & article data
It is thought to constituting 0.4-4% of cases non-small cell lung cancer.
- cigarette smoking 8
The definition of adenosquamous carcinoma indicates a carcinoma showing components of adenocarcinoma and squamous cell carcinoma, with each comprising at least 10% of the tumor 4.
There may be a slight predominance towards the periphery of the lung 5-6.
There appears to be a wide imaging spectrum both in terms of size and morphology 5. Differentiation from other histological forms on imaging grounds alone can be difficult, if not impossible. They usually present as a single lesion, with mean tumor size ranging from 2.8 to 3.8 cm (range 0.6-11 cm), based on two studies 5-6.
Treatment and prognosis
It is thought to be more aggressive than both pure adenocarcinomas of the lung and pure squamous cell carcinomas of the lung 1. The early-stage disease may be amenable to surgery. There may also be an increased rate of lymph node metastases at the time of presentation compared with other histological types 7.
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- 2. Naunheim KS, Taylor JR, Skosey C et-al. Adenosquamous lung carcinoma: clinical characteristics, treatment, and prognosis. Ann. Thorac. Surg. 1987;44 (5): 462-6. Pubmed citation
- 3. Gawrychowski J, BrulińSki K, Malinowski E et-al. Prognosis and survival after radical resection of primary adenosquamous lung carcinoma. Eur J Cardiothorac Surg. 2005;27 (4): 686-92. Eur J Cardiothorac Surg (full text) - doi:10.1016/j.ejcts.2004.12.030 - Pubmed citation
- 4. Tochigi N, Dacic S, Nikiforova M et-al. Adenosquamous carcinoma of the lung: a microdissection study of KRAS and EGFR mutational and amplification status in a western patient population. Am. J. Clin. Pathol. 2011;135 (5): 783-9. Am. J. Clin. Pathol. (full text) - doi:10.1309/AJCP08IQZAOGYLFL - Pubmed citation
- 5. Kazerooni EA, Bhalla M, Shepard JA et-al. Adenosquamous carcinoma of the lung: radiologic appearance. AJR Am J Roentgenol. 1994;163 (2): 301-6. doi:10.2214/ajr.163.2.8037019 - Pubmed citation
- 6. Yu JQ, Yang ZG, Austin JH et-al. Adenosquamous carcinoma of the lung: CT-pathological correlation. Clin Radiol. 2005;60 (3): 364-9. doi:10.1016/j.crad.2004.08.014 - Pubmed citation
- 7. Hsia JY, Chen CY, Hsu CP et-al. Adenosquamous carcinoma of the lung. Surgical results compared with squamous cell and adenocarcinoma. Scand. Cardiovasc. J. 1999;33 (1): 29-32. Pubmed citation
- 8. Li C, Lu H. Adenosquamous carcinoma of the lung. (2018) OncoTargets and therapy. 11: 4829-4835. doi:10.2147/OTT.S164574 - Pubmed