Adrenal hyperplasia

Adrenal hyperplasia refers to nonmalignant growth (enlargement) of the adrenal glands and is a rare cause of ACTH-independent Cushing syndrome with unilateral adrenal cortical adenomas being the commonest. 20% of Conn syndrome cases are secondary to adrenal hyperplasia.  In diffuse hyperplasia, the limbs of the adrenal glands are >5 cm in length and >10 mm in thickness. 


Adrenal hyperplasia can be classified according to:

  • enlarged limbs of one or both adrenal glands >10 mm
  • normal adrenal morphology maintained
  • nodular or uniform
  • high lipid content and thus may demonstrate signal drop out in out-of-phase imaging
  • signal drop out due to lipid content overlaps with adrenal cortical adenomas
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Article Information

rID: 17118
System: Urogenital
Section: Pathology
Synonyms or Alternate Spellings:
  • Adrenal cortical hyperplasia
  • Adrenal hyperplasia : general

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