Adrenal lymphoma

Last revised by Yuranga Weerakkody on 6 Feb 2022

Adrenal lymphoma can refer to:

  • primary adrenal lymphoma: rare 
    • can be bilateral in around 70% of cases 1
  • secondary involvement of the adrenal glands with lymphoma: more common

Clinical presentation

The presentation can be variable and may include adrenal insufficiency, worsening general state, weight loss, and abdominal pain.

Radiographic features


Maybe seen as bulky adrenal masses. Often difficult to use bilaterality to differentiate primary versus secondary since the former can be bilateral in a considerable portion of cases. 

Usually of soft tissue attenuation (40-60 HU) with mild progressive enhancement after contrast medium administration 9.

Nuclear medicine
  • often FDG avid 6

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Cases and figures

  • Case 1: adrenal lymphoma
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  • Case 2
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  • Case 3
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