Adrenal lymphoma

Last revised by Dr Mohamed Saber on 08 Mar 2021

Adrenal lymphoma can refer to:

  • primary adrenal lymphoma: rare 
    • can be bilateral in around 70% of cases 1
  • secondary involvement of the adrenal glands with lymphoma: more common

Clinical presentation

The presentation can be variable and may include adrenal insufficiency, worsening general state, weight loss, and abdominal pain.

Radiographic features

CT/MRI

Maybe seen as bulky adrenal masses. Often difficult to use bilaterality to differentiate primary versus secondary since the former can be bilateral in a considerable portion of cases. 

Usually of soft tissue attenuation (40-60 HU) with mild progressive enhancement after contrast medium administration 9.

Nuclear medicine
  • often FDG avid 6

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Cases and figures

  • Case 1: adrenal lymphoma
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  • Case 2
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