Adrenal myelolipomas are rare, benign and usually asymptomatic tumors of the adrenal gland characterized by the predominance of mature adipocytes.
On imaging, they usually present as large masses with a variable amount of fat-containing components.
Rare tumors with estimated autopsy prevalence of 0.1-0.2%. They are usually identified in adults, either incidentally or if complicated by hemorrhage (see below). There is no gender predilection 9.
Most lesions are asymptomatic 6 and may be discovered incidentally when the region is imaged for other reasons (i.e. an incidentaloma). Larger lesions (typically over 4 cm in size) can present with an acute retroperitoneal hemorrhage, and still others (especially when very large) with vague mass-related symptoms 9. There may be a right-sided predilection 5.
Although the tumor itself is non-functioning there is a relatively high incidence (10%) of associated endocrine disorders 9:
- Cushing syndrome
- congenital adrenal hyperplasia (21-hydroxylase deficiency)
- Conn syndrome (primary hyperaldosteronism)
- rarely it can present in extra-adrenal locations 16
Histological examination demonstrates variable amounts of:
- mature adipocytes (with distended lipid vacuoles) similar to bone marrow
- hematopoietic cells (including cells from myeloid, erythroid and megakaryocytic cell lines)
The fatty component is often the predominant feature and therefore the most characteristic feature on imaging. The lesions can infrequently contain bone 10 or show partial replacement by hemorrhage or fibrosis.
Exact sonographic appearances are varied depending on individual tumor components 1. Usually is seen as a heterogeneous mass of mixed hyper- and hypoechoic components with the former primarily resulting from fatty portions. Areas of hemorrhage appear hypoechoic on ultrasonography 19.
The CT appearance is usually characteristic. The typical adrenal myelolipoma appears as an adrenal lesion with fat-containing components. The mass is usually relatively well circumscribed, however masses that are mostly fat may be difficult to separate from surrounding retroperitoneal fat.
The amount of fatty component is variable, ranging from only a few small regions in an otherwise mostly soft tissue density mass (10%) to masses made up of roughly equal components of fat and soft tissue (50%) or almost completely composed of fatty tissue (40%) 9. The soft tissue and fatty components can be sufficiently mixed in some cases to render the mass a density similar to fluid.
Small punctate calcifications may be seen in 25-30% of cases 4,9.
If hemorrhage is present then regions of higher attenuation may be seen. This is more frequently seen in large lesions (>10 cm) 3.
- T1: typically hyperintense due to fat contents
- T1 (FS): typically shows fat suppression
- T2: generally intermediate to hyperintense but can sometimes vary depending on contents (especially blood products)
- T1 C+ (Gd): shows striking enhancement 1
- in and out of phase: in masses with mixed components, out of phase imaging may demonstrate signal loss as the microscopic fat cells usually have little intracellular water 9,11
Adrenal myelolipomas typically do not demonstrate avid FDG uptake and it is generally lower than that of the liver background. However, in rare cases the adenomatous and hematopoietic elements can show an increased FDG uptake 12,13.
Treatment and prognosis
They are benign lesions histologically and there is currently no recognized malignant potential 5. As such, if imaging features are characteristic and the lesion is small, no treatment is required.
If imaging findings are indeterminate, percutaneous biopsy can be performed. In larger lesions or where hemorrhage has occurred surgical excision is curative.
History and etymology
Initially described by Edgar von Gierke 6 in 1905 with the term myelolipoma coined by the French pathologist Charles Obenling (1895-1960) in 1929 7,17,18.
General imaging differential considerations include:
- retroperitoneal liposarcoma
- fat-containing adrenocortical carcinoma
- lipid-rich adrenal adenoma
- adrenal teratoma: extremely rare
renal angiomyolipoma (AML)
- CT coronal reconstruction or MRI can help in determining the kidney as the origin of the lesion
- adrenal angiomyolipoma 14
- adrenal lipoma: very rare
- extra adrenal myelolipoma
- 1. Cyran KM, Kenney PJ, Memel DS et-al. Adrenal myelolipoma. AJR Am J Roentgenol. 1996;166 (2): 395-400. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Bhansali A, Kotwal N, Ganpathi B. Adrenal myelolipoma. Postgrad Med J. 2001;77 (910): 513. doi:10.1136/pmj.77.910.513 - Free text at pubmed - Pubmed citation
- 3. Routhier JR, Woodfield CA, Mayo-smith WW. AJR teaching file: fat-containing retroperitoneal mass presenting with acute flank pain. AJR Am J Roentgenol. 2009;192 (6): S122-4. doi:10.2214/AJR.07.7007 - Pubmed citation
- 4. Craig WD, Fanburg-smith JC, Henry LR et-al. Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. Radiographics. 29 (1): 261-90. doi:10.1148/rg.291085203 - Pubmed citation
- 5. Kenney PJ, Wagner BJ, Rao P et-al. Myelolipoma: CT and pathologic features. Radiology. 1998;208 (1): 87-95. Radiology (abstract) - Pubmed citation
- 6. Gierke E. Uber knochenmarksgewebe in den nebenniene. Beitn Path Anat 1905; 7:311-325.
- 7. Oberling C. Les formations myelolipomatouses. Bull Cancer 1929; 18:234-246.
- 8. Palmer WE, Gerard-mcfarland EL, Chew FS. Adrenal myelolipoma. AJR Am J Roentgenol. 1991;156 (4): 724. AJR Am J Roentgenol (citation) - Pubmed citation
- 9. Lee JK. Computed body tomography with MRI correlation. Lippincott Williams & Wilkins. (2006) ISBN:0781745268. Read it at Google Books - Find it at Amazon
- 10. Rossi A, Incensati R. Bone tissue in adrenal myelolipoma: a case report. Tumori. 84 (1): 90-3. - Pubmed citation
- 11. Brant WE, Helms CA. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. (2007) ISBN:0781761352. Read it at Google Books - Find it at Amazon
- 12. Dong A, Cui Y, Wang Y et-al. (18)F-FDG PET/CT of adrenal lesions. AJR Am J Roentgenol. 2014;203 (2): 245-52. doi:10.2214/AJR.13.11793 - Pubmed citation
- 13. Elaini AB, Shetty SK, Chapman VM et-al. Improved detection and characterization of adrenal disease with PET-CT. Radiographics. 2007;27 (3): 755-67. doi:10.1148/rg.273055031 - Pubmed citation
- 14. Antar A, Boyle A, Patel T. Angiomyolipoma of the Adrenal Gland: A Case Presentation and a Review of Adrenal Lipomatous Tumors. (2017) Urology case reports. 12: 59-61. doi:10.1016/j.eucr.2016.11.004 - Pubmed
- 15. Schieda N, Siegelman ES. Update on CT and MRI of Adrenal Nodules. (2017) AJR. American journal of roentgenology. 208 (6): 1206-1217. doi:10.2214/AJR.16.17758 - Pubmed
- 16. Hakim A, Rozeik C. Adrenal and extra-adrenal myelolipomas - a comparative case report. (2014) Journal of radiology case reports. 8 (1): 1-12. doi:10.3941/jrcr.v8i1.1551 - Pubmed
- 17. Pillay Y. Abdominal wall extra-adrenal myelolipoma, a case report and review of the literature. (2018) Journal of surgical case reports. 2018 (4): rjy063. doi:10.1093/jscr/rjy063 - Pubmed
- 18. Charles Oberling (1895-1960): A Herald of Modern Oncology:. (2016) International Journal of Surgical Pathology. 11 (2): 109-15. doi:10.1177/106689690301100206 - Pubmed
- 19. Maria R. Bokhari, Hassam Zulfiqar, Vishnu V. Garla. Adrenal Myelolipoma. (2020) Pubmed
Related Radiopaedia articles
- adrenal gland anatomy
- adrenal adenoma
- adrenal metastasis
- adrenal cortical hyperplasia
- adrenal cortical carcinoma
- adrenal granulomatous disease
- adrenal lipoma
- adrenal myelolipoma
- adrenal hemorrhage
- adrenal abscess
- adrenal hemangioma
- adrenal cyst
- adrenal lymphangioma
- adrenal haemangiosarcoma
- adrenal lymphoma
- extramedullary hematopoiesis in adrenal gland
- tumors of the adrenal gland
- Management of Incidental Adrenal Masses: ACR White Paper
- differential diagnoses