Adult granulosa cell tumour of the ovary
Adult granulosa cell tumour of the ovary is a type of ovarian sex cord / stromal tumour. They are by far the most frequent subtype of granulosa cell tumours of the ovary (95%) and are commoner than the juvenile granulosa tumour of the ovary.
Approximately two-thirds of this subtype are discovered in postmenopausal women (peak incidence 50-55 years old).
The tumours often produce oestrogen and may present with abnormal vaginal bleeding.
Macroscopically, typical adult ovarian granulosa cell tumours form large multiseptated cystic masses or solid masses with variable amounts of cystic components. These cystic components often contain haemorrhage.
Microscopically, the tumour cells have pale nuclei that frequently have regular follicles without mucin. They also have longitudinal grooves that grow in sheets, trabecular patterns, or strands with gland-like structures filled with an acidophilic material recalling immature follicles (Call-Exner bodies).
- there can be accompanying endometrial hyperplasia due to oestrogen secretion
- appearance varies widely: from a solid mass to a multiloculated solid-cystic mass, to a purely cystic lesion
- varying degrees of haemorrhage and fibrosis
- less likely to have intracystic papillary projections than epithelial ovarian tumours
- 1. Pectasides D, Papaxoinis G, Fountzilas G et-al. Adult granulosa cell tumors of the ovary: a clinicopathological study of 34 patients by the Hellenic Cooperative Oncology Group (HeCOG). Anticancer Res. 28 (2B): 1421-7. Anticancer Res. (link) - Pubmed citation
- 2. Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J. Clin. Oncol. 2003;21 (6): 1180-9. doi:10.1200/JCO.2003.10.019 - Pubmed citation