Adult granulosa cell tumor of the ovary

Dr Yuranga Weerakkody and Radswiki et al.

Adult granulosa cell tumor of the ovary is a type of ovarian sex cord / stromal tumor. They are by far the most frequent subtype of granulosa cell tumors of the ovary (95%) and are commoner than the juvenile granulosa tumor of the ovary.

Approximately two-thirds of this subtype are discovered in postmenopausal women (peak incidence 50-55 years old).

The tumors often produce estrogen and may present with abnormal vaginal bleeding.

Macroscopically, typical adult ovarian granulosa cell tumors form large multiseptated cystic masses or solid masses with variable amounts of cystic components. These cystic components often contain hemorrhage.
Microscopically, the tumor cells have pale nuclei that frequently have regular follicles without mucin. They also have longitudinal grooves that grow in sheets, trabecular patterns, or strands with gland-like structures filled with an acidophilic material recalling immature follicles (Call-Exner bodies).

  • appearance varies widely: from a solid mass to a multiloculated solid-cystic mass, to a purely cystic lesion
  • varying degrees of hemorrhage and fibrosis
  • less likely to have intracystic papillary projections than epithelial ovarian tumors

Article information

rID: 15398
System: Gynaecology
Synonyms or Alternate Spellings:
  • Adult granulosa cell tumour of ovary
  • Adult ovarian granulosa
  • Adult granulosa cell tumours of the ovary
  • Adult granulosa cell tumors of the ovary

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Cases and figures

  • Figure 1: histology
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  • Case 1
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  • Case 2
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