Dr Jeremy Jones et al.

Aflatoxins are naturally occuring mycotoxins that are produced by Aspergillus species, especially Aspergillus flavus. They are acutely toxic and carcinogenic.

Acute exposure

High-level aflatoxin exposure can result acute aflatoxicosis with acute hepatic necrosis, resulting in cirrhosis, and potentially hepatocellular carcinoma

Chronic exposure

Chronic, subclinical exposure doesn't result in afaloxoicosis.  In children, may cause developmental delay and growth retardation. Chronic exposure can also result in increased risk of hepatocellular carcinoma. 

Aflatoxin metabolites can intercalate into DNA resulting in mutation of p53, one of the tumour supressor genes.  Some base pair locations are preferentially affected, e.g. the third base of codon 249 1.

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Article information

rID: 13559
System: Chest
Synonyms or Alternate Spellings:
  • Aflatoxin

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