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Chronic, subclinical exposure does not result in aflatoxicosis. In children, it may cause developmental delay and growth retardation. Chronic exposure can also result in increased risk of hepatocellular carcinoma.
Aflatoxin metabolites can intercalate into DNA resulting in mutation of p53, one of the tumor suppressor genes. Some base pair locations are preferentially affected, e.g. the third base of codon 249 1.
- 1. Aguilar F, Hussain SP, Cerutti P. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 1993;90 (18): 8586-90. Proc. Natl. Acad. Sci. U.S.A. (abstract) - Free text at pubmed - Pubmed citation
- 2. Aflatoxin from Wikipedia, the free encyclopedia. Aflatoxin