AIDS-related diffuse large B-cell lymphomas are one of the immunodeficiency-associated CNS lymphomas, and in Western countries represented a dramatic increase in primary CNS lymphoma during the HIV/AIDS epidemic of the 1980s, although the incidence is likely lower in patients treated with antiretroviral therapy (ART) 1.
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Pathology
Like other immunodeficiency-associated CNS lymphomas, AIDS-related lymphomas tend to be EBV-related 1.
Radiographic features
Imaging is similar to other immunodeficiency-associated CNS lymphomas, with tumors more likely to be necrotic, heterogeneous and multifocal 1.
Differential diagnosis
A particularly challenging differential diagnosis is cerebral toxoplasmosis. See cerebral toxoplasmosis vs primary CNS lymphoma.
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