AIDS-related diffuse large B-cell lymphoma

Last revised by Rohit Sharma on 18 Apr 2022

AIDS-related diffuse large B-cell lymphomas are one of the immunodeficiency-associated CNS lymphomas, and in Western countries represented a dramatic increase in primary CNS lymphoma during the HIV/AIDS epidemic of the 1980s, although the incidence is likely lower in patients treated with antiretroviral therapy (ART) 1

Like other immunodeficiency-associated CNS lymphomas, AIDS-related lymphomas tend to be EBV-related 1

Imaging is similar to other immunodeficiency-associated CNS lymphomas, with tumors more likely to be necrotic, heterogeneous and multifocal 1

A particularly challenging differential diagnosis is cerebral toxoplasmosis. See cerebral toxoplasmosis vs primary CNS lymphoma.

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