Alcian blue stain

Last revised by Joachim Feger on 18 Sep 2021

Alcian blue stain is a histological stain utilized for the identification of extracellular matrix proteoglycans, like glycosaminoglycans and hyaluronic acid 1, commonly in connective tissue and epithelial malignant neoplasms 2, and also Barrett esophagus, where it can highlight mucosal intestinal metaplasia 3.

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